Drug interactions
Clomipramine + Umeclidinium-vilanterol
Severity: Major
Clomipramine and Umeclidinium-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of beta-agonists such as vilanterol, causing tachycardia, hypertension and arrhythmia. Clomipramine also prolongs QT and has anticholinergic effects that may add to umeclidinium.
What this interaction means in plain words
Clomipramine and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive adrenergic cardiovascular stimulation and QT prolongation, with additive anticholinergic effects.
What to do
Avoid the combination where possible, or use with close monitoring of heart rate, blood pressure and ECG. Watch for anticholinergic effects such as urinary retention and dry mouth.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Clomipramine and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants can potentiate the cardiovascular effects of beta-agonists such as vilanterol, causing tachycardia, hypertension and arrhythmia. Clomipramine also prolongs QT and has anticholinergic effects that may add to umeclidinium.
How serious is the interaction between Clomipramine and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use with close monitoring of heart rate, blood pressure and ECG. Watch for anticholinergic effects such as urinary retention and dry mouth.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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