Interações medicamentosas
Clotrimazole + Eliglustat
Gravidade: Moderada
Clotrimazole and Eliglustat: moderate interaction.
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Resumo
Clotrimazole may increase eliglustat exposure through CYP3A4 inhibition, which can prolong the PR, QRS and QT intervals at high concentrations. The risk is greatest in poor or intermediate CYP2D6 metabolizers.
O que esta interação significa em palavras simples
Clotrimazole and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clotrimazole belongs to Anti Fungals; Eliglustat belongs to Miscellaneous.
Por que acontece
Clotrimazole inhibits CYP3A4, which contributes to eliglustat metabolism, particularly when CYP2D6 is limited.
O que fazer
Prefer topical clotrimazole with minimal absorption or an alternative antifungal. If systemic use is needed, check CYP2D6 status and monitor ECG, adjusting eliglustat per labeling.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Clotrimazole
- Clotrimazole + Lomitapide Grave
- Clotrimazole + Mavacamten Grave
- Clotrimazole + Mobocertinib Grave
- Clotrimazole + Voclosporin Grave
- Bosutinib + Clotrimazole Moderada
- Cannabidiol + Clotrimazole Moderada
Outras interações de Eliglustat
- Amiodarone + Eliglustat Contraindicada
- Clarithromycin + Eliglustat Contraindicada
- Dronedarone + Eliglustat Contraindicada
- Eliglustat + Itraconazole Contraindicada
- Eliglustat + Ketoconazole Contraindicada
- Eliglustat + Pimozide Contraindicada
Perguntas frequentes
Can I take Clotrimazole with Eliglustat?
MediHelp rates the interaction as moderate. Clotrimazole and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clotrimazole may increase eliglustat exposure through CYP3A4 inhibition, which can prolong the PR, QRS and QT intervals at high concentrations. The risk is greatest in poor or intermediate CYP2D6 metabolizers.
How serious is the interaction between Clotrimazole and Eliglustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer topical clotrimazole with minimal absorption or an alternative antifungal. If systemic use is needed, check CYP2D6 status and monitor ECG, adjusting eliglustat per labeling.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
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