Interações medicamentosas
Clozapine + Vorinostat
Gravidade: Grave
Clozapine and Vorinostat: major interaction.
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Resumo
Vorinostat has been associated with QT prolongation, and clozapine can have the same effect. Concurrent use may increase the risk of serious ventricular arrhythmias.
O que esta interação significa em palavras simples
Clozapine and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Vorinostat belongs to Oncology.
Por que acontece
Additive pharmacodynamic QT prolongation.
O que fazer
Avoid the combination if an alternative exists. If it is necessary, monitor ECG and keep potassium and magnesium within normal range.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Clozapine
- Clozapine + Deferiprone Contraindicada
- Clozapine + Irinotecan Contraindicada
- Clozapine + Pimozide Contraindicada
- Clozapine + Thioridazine Contraindicada
- Acalabrutinib + Clozapine Grave
- Adagrasib + Clozapine Grave
Outras interações de Vorinostat
- Thioridazine + Vorinostat Contraindicada
- Amiodarone + Vorinostat Grave
- Amisulpride + Vorinostat Grave
- Anagrelide + Vorinostat Grave
- Asenapine + Vorinostat Grave
- Chlorpromazine + Vorinostat Grave
Perguntas frequentes
Can I take Clozapine with Vorinostat?
MediHelp rates the interaction as major. Clozapine and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vorinostat has been associated with QT prolongation, and clozapine can have the same effect. Concurrent use may increase the risk of serious ventricular arrhythmias.
How serious is the interaction between Clozapine and Vorinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists. If it is necessary, monitor ECG and keep potassium and magnesium within normal range.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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