Interações medicamentosas
Cyclosporin + Glycerol phenylbutyrate
Gravidade: Moderada
Cyclosporin and Glycerol phenylbutyrate: moderate interaction.
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Resumo
Glycerol phenylbutyrate is a weak CYP3A4 inducer and may lower cyclosporine concentrations. Reduced exposure could compromise immunosuppression.
O que esta interação significa em palavras simples
Cyclosporin and Glycerol phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Glycerol phenylbutyrate belongs to Miscellaneous.
Por que acontece
Weak induction of CYP3A4 increases cyclosporine metabolism.
O que fazer
Monitor cyclosporine trough levels after starting or stopping glycerol phenylbutyrate and adjust the dose if needed.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicada
- Aliskiren + Cyclosporin Contraindicada
- Bcg vaccine live + Cyclosporin Contraindicada
- Bosentan + Cyclosporin Contraindicada
- Cidofovir + Cyclosporin Contraindicada
- Cyclosporin + Dengue vaccine Contraindicada
Outras interações de Glycerol phenylbutyrate
- Dexamethasone + Glycerol phenylbutyrate Grave
- Glycerol phenylbutyrate + Sodium valproate Grave
- Glycerol phenylbutyrate + Valproic acid Grave
- Dexamethasone-neomycin-polymyxin + Glycerol phenylbutyrate Moderada
- Dexamethasone-tobramycin + Glycerol phenylbutyrate Moderada
- Fludrocortisone + Glycerol phenylbutyrate Moderada
Perguntas frequentes
Can I take Cyclosporin with Glycerol phenylbutyrate?
MediHelp rates the interaction as moderate. Cyclosporin and Glycerol phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glycerol phenylbutyrate is a weak CYP3A4 inducer and may lower cyclosporine concentrations. Reduced exposure could compromise immunosuppression.
How serious is the interaction between Cyclosporin and Glycerol phenylbutyrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels after starting or stopping glycerol phenylbutyrate and adjust the dose if needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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