Interações medicamentosas
Dexamethasone + Glycerol phenylbutyrate
Gravidade: Grave
Dexamethasone and Glycerol phenylbutyrate: major interaction.
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Resumo
Corticosteroids promote protein catabolism and can raise ammonia, working against the ammonia-lowering aim of glycerol phenylbutyrate in urea cycle disorders. This can precipitate hyperammonemia.
O que esta interação significa em palavras simples
Dexamethasone and Glycerol phenylbutyrate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone belongs to Endocrine; Glycerol phenylbutyrate belongs to Miscellaneous.
Por que acontece
Glucocorticoid-induced protein breakdown increases nitrogen load and plasma ammonia, opposing the nitrogen scavenging action.
O que fazer
Monitor plasma ammonia closely and adjust the glycerol phenylbutyrate dose or protein intake if ammonia rises; avoid unnecessary steroid use.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicada
- Dexamethasone + Mifepristone Contraindicada
- Dexamethasone + Rilpivirine Contraindicada
- Dexamethasone + Smallpox vaccine live Contraindicada
- Dexamethasone + Varicella virus vaccine live Contraindicada
- Dexamethasone + Yellow fever vaccine Contraindicada
Outras interações de Glycerol phenylbutyrate
- Glycerol phenylbutyrate + Sodium valproate Grave
- Glycerol phenylbutyrate + Valproic acid Grave
- Cyclosporin + Glycerol phenylbutyrate Moderada
- Dexamethasone-neomycin-polymyxin + Glycerol phenylbutyrate Moderada
- Dexamethasone-tobramycin + Glycerol phenylbutyrate Moderada
- Fludrocortisone + Glycerol phenylbutyrate Moderada
Perguntas frequentes
Can I take Dexamethasone with Glycerol phenylbutyrate?
MediHelp rates the interaction as major. Dexamethasone and Glycerol phenylbutyrate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Corticosteroids promote protein catabolism and can raise ammonia, working against the ammonia-lowering aim of glycerol phenylbutyrate in urea cycle disorders. This can precipitate hyperammonemia.
How serious is the interaction between Dexamethasone and Glycerol phenylbutyrate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely and adjust the glycerol phenylbutyrate dose or protein intake if ammonia rises; avoid unnecessary steroid use.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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