Interações medicamentosas
Dexamethasone-neomycin-polymyxin + Glycerol phenylbutyrate
Gravidade: Moderada
Dexamethasone-neomycin-polymyxin and Glycerol phenylbutyrate: moderate interaction.
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Resumo
Corticosteroids promote protein catabolism and may raise plasma ammonia, opposing the ammonia-lowering effect of glycerol phenylbutyrate in urea cycle disorders. This could precipitate hyperammonemia, which is dangerous.
O que esta interação significa em palavras simples
Dexamethasone-neomycin-polymyxin and Glycerol phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Glycerol phenylbutyrate belongs to Miscellaneous.
Por que acontece
Corticosteroid-induced protein catabolism increases ammonia production, counteracting the nitrogen-scavenging effect.
O que fazer
Monitor plasma ammonia closely when systemic dexamethasone is used. Adjust the glycerol phenylbutyrate dose as needed.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Grave
- Dexamethasone-neomycin-polymyxin + Lapatinib Grave
- Dexamethasone-neomycin-polymyxin + Levofloxacin Grave
- Dexamethasone-neomycin-polymyxin + Mifepristone Grave
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Grave
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderada
Outras interações de Glycerol phenylbutyrate
Perguntas frequentes
Can I take Dexamethasone-neomycin-polymyxin with Glycerol phenylbutyrate?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Glycerol phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids promote protein catabolism and may raise plasma ammonia, opposing the ammonia-lowering effect of glycerol phenylbutyrate in urea cycle disorders. This could precipitate hyperammonemia, which is dangerous.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Glycerol phenylbutyrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely when systemic dexamethasone is used. Adjust the glycerol phenylbutyrate dose as needed.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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