Interações medicamentosas
Fludrocortisone + Glycerol phenylbutyrate
Gravidade: Moderada
Fludrocortisone and Glycerol phenylbutyrate: moderate interaction.
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Resumo
Corticosteroids promote protein breakdown and can raise plasma ammonia, which counteracts the ammonia-lowering goal of glycerol phenylbutyrate in urea cycle disorders. This may risk hyperammonemia.
O que esta interação significa em palavras simples
Fludrocortisone and Glycerol phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Glycerol phenylbutyrate belongs to Miscellaneous.
Por que acontece
Corticosteroid-driven protein catabolism increases nitrogen load and ammonia production, opposing the nitrogen scavenging effect.
O que fazer
Monitor plasma ammonia closely when fludrocortisone is started or adjusted, and adjust the glycerol phenylbutyrate dose or protein intake as needed.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Fludrocortisone
Outras interações de Glycerol phenylbutyrate
- Dexamethasone + Glycerol phenylbutyrate Grave
- Glycerol phenylbutyrate + Sodium valproate Grave
- Glycerol phenylbutyrate + Valproic acid Grave
- Cyclosporin + Glycerol phenylbutyrate Moderada
- Dexamethasone-neomycin-polymyxin + Glycerol phenylbutyrate Moderada
- Dexamethasone-tobramycin + Glycerol phenylbutyrate Moderada
Perguntas frequentes
Can I take Fludrocortisone with Glycerol phenylbutyrate?
MediHelp rates the interaction as moderate. Fludrocortisone and Glycerol phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids promote protein breakdown and can raise plasma ammonia, which counteracts the ammonia-lowering goal of glycerol phenylbutyrate in urea cycle disorders. This may risk hyperammonemia.
How serious is the interaction between Fludrocortisone and Glycerol phenylbutyrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely when fludrocortisone is started or adjusted, and adjust the glycerol phenylbutyrate dose or protein intake as needed.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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