Interações medicamentosas
Cyclosporine + Upadacitinib
Gravidade: Contraindicada
Cyclosporine and Upadacitinib: contraindicated interaction.
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Resumo
Cyclosporine is a potent immunosuppressant, and combined with upadacitinib it increases the risk of serious infection and malignancy. Upadacitinib labeling advises against use with potent immunosuppressants such as cyclosporine.
O que esta interação significa em palavras simples
Cyclosporine and Upadacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Additive immunosuppression through calcineurin and JAK inhibition.
O que fazer
Avoid the combination. Choose a regimen that does not pair a JAK inhibitor with cyclosporine.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Upadacitinib
- Abrocitinib + Upadacitinib Contraindicada
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicada
- Baricitinib + Upadacitinib Contraindicada
- Bcg vaccine live + Upadacitinib Contraindicada
- Dengue vaccine + Upadacitinib Contraindicada
- Influenza virus vaccine quadrivalent intranasal + Upadacitinib Contraindicada
Perguntas frequentes
Can I take Cyclosporine with Upadacitinib?
MediHelp rates the interaction as contraindicated. Cyclosporine and Upadacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cyclosporine is a potent immunosuppressant, and combined with upadacitinib it increases the risk of serious infection and malignancy. Upadacitinib labeling advises against use with potent immunosuppressants such as cyclosporine.
How serious is the interaction between Cyclosporine and Upadacitinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Choose a regimen that does not pair a JAK inhibitor with cyclosporine.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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