Interações medicamentosas
Dacomitinib + Imipramine
Gravidade: Grave
Dacomitinib and Imipramine: major interaction.
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Resumo
Dacomitinib strongly inhibits CYP2D6, which is a main route of imipramine metabolism, so tricyclic levels may increase. Higher exposure raises the risk of anticholinergic effects, sedation, arrhythmia and QT prolongation.
O que esta interação significa em palavras simples
Dacomitinib and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dacomitinib belongs to Oncology; Imipramine belongs to Central Nervous System.
Por que acontece
Dacomitinib inhibits CYP2D6, reducing imipramine clearance.
O que fazer
Avoid if possible, or reduce the imipramine dose and monitor for toxicity. Consider ECG and tricyclic levels.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Imipramine
- Dronedarone + Imipramine Contraindicada
- Imipramine + Isocarboxazid Contraindicada
- Imipramine + Phenelzine Contraindicada
- Imipramine + Pimozide Contraindicada
- Imipramine + Rasagiline Contraindicada
- Imipramine + Safinamide Contraindicada
Outras interações de Dacomitinib
- Dacomitinib + Thioridazine Contraindicada
- Amitriptyline + Dacomitinib Grave
- Atomoxetine + Dacomitinib Grave
- Brexpiprazole + Dacomitinib Grave
- Clomipramine + Dacomitinib Grave
- Dacomitinib + Desipramine Grave
Perguntas frequentes
Can I take Dacomitinib with Imipramine?
MediHelp rates the interaction as major. Dacomitinib and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dacomitinib strongly inhibits CYP2D6, which is a main route of imipramine metabolism, so tricyclic levels may increase. Higher exposure raises the risk of anticholinergic effects, sedation, arrhythmia and QT prolongation.
How serious is the interaction between Dacomitinib and Imipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or reduce the imipramine dose and monitor for toxicity. Consider ECG and tricyclic levels.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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