Interações medicamentosas
Dasatinib + Nizatidine
Gravidade: Grave
Dasatinib and Nizatidine: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Dasatinib absorption depends on an acidic gastric environment, and H2 blockers raise gastric pH. Exposure to dasatinib may fall, risking reduced antileukemic efficacy.
O que esta interação significa em palavras simples
Dasatinib and Nizatidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Nizatidine belongs to Gastrointestinal Tract.
Por que acontece
Reduced pH-dependent dissolution and absorption of dasatinib due to gastric acid suppression.
O que fazer
Avoid H2 blockers with dasatinib; use short-acting antacids instead, given about 2 hours before or after dasatinib.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Nizatidine
- Atazanavir + Nizatidine Grave
- Erlotinib + Nizatidine Grave
- Itraconazole + Nizatidine Grave
- Ketoconazole + Nizatidine Grave
- Nizatidine + Pazopanib Grave
- Nizatidine + Rilpivirine Grave
Outras interações de Dasatinib
- Dasatinib + Saquinavir Contraindicada
- Dasatinib + Thioridazine Contraindicada
- Adagrasib + Dasatinib Grave
- Amiodarone + Dasatinib Grave
- Amisulpride + Dasatinib Grave
- Amitriptyline + Dasatinib Grave
Perguntas frequentes
Can I take Dasatinib with Nizatidine?
MediHelp rates the interaction as major. Dasatinib and Nizatidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasatinib absorption depends on an acidic gastric environment, and H2 blockers raise gastric pH. Exposure to dasatinib may fall, risking reduced antileukemic efficacy.
How serious is the interaction between Dasatinib and Nizatidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid H2 blockers with dasatinib; use short-acting antacids instead, given about 2 hours before or after dasatinib.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Erlotinib, Itraconazole. The full list is on the Nizatidine page.
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