Interações medicamentosas
Erlotinib + Nizatidine
Gravidade: Grave
Erlotinib and Nizatidine: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Erlotinib solubility falls as pH rises, so acid-reducing agents lower its absorption. This may reduce erlotinib exposure and antitumor efficacy.
O que esta interação significa em palavras simples
Erlotinib and Nizatidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erlotinib belongs to Oncology; Nizatidine belongs to Gastrointestinal Tract.
Por que acontece
Decreased pH-dependent dissolution of erlotinib caused by gastric acid suppression.
O que fazer
If an H2 blocker is needed, take erlotinib at least 2 hours before or 10 hours after the H2 blocker. Avoid the combination when practical.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Erlotinib e Nizatidine, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Nizatidine
- Atazanavir + Nizatidine Grave
- Dasatinib + Nizatidine Grave
- Itraconazole + Nizatidine Grave
- Ketoconazole + Nizatidine Grave
- Nizatidine + Pazopanib Grave
- Nizatidine + Rilpivirine Grave
Outras interações de Erlotinib
- Amobarbital + Erlotinib Grave
- Apalutamide + Erlotinib Grave
- Carbamazepine + Erlotinib Grave
- Cobicistat + Erlotinib Grave
- Darunavir + Erlotinib Grave
- Dexlansoprazole + Erlotinib Grave
Perguntas frequentes
Can I take Erlotinib with Nizatidine?
MediHelp rates the interaction as major. Erlotinib and Nizatidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erlotinib solubility falls as pH rises, so acid-reducing agents lower its absorption. This may reduce erlotinib exposure and antitumor efficacy.
How serious is the interaction between Erlotinib and Nizatidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If an H2 blocker is needed, take erlotinib at least 2 hours before or 10 hours after the H2 blocker. Avoid the combination when practical.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Dasatinib, Itraconazole. The full list is on the Nizatidine page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
