Interações medicamentosas
Deferiprone + Vorinostat
Gravidade: Grave
Deferiprone and Vorinostat: major interaction.
Última atualização
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Resumo
Deferiprone can cause agranulocytosis and neutropenia, and vorinostat commonly causes cytopenias, particularly thrombocytopenia and sometimes neutropenia. Combined use may increase the risk of severe bone marrow suppression and infection.
O que esta interação significa em palavras simples
Deferiprone and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferiprone belongs to Miscellaneous; Vorinostat belongs to Oncology.
Por que acontece
Additive pharmacodynamic myelosuppressive effects.
O que fazer
Avoid concurrent use if an alternative is available. If unavoidable, monitor absolute neutrophil count and platelets frequently and stop deferiprone if neutropenia occurs.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Deferiprone
- Clozapine + Deferiprone Contraindicada
- Abemaciclib + Deferiprone Grave
- Acalabrutinib + Deferiprone Grave
- Ado-trastuzumab emtansine + Deferiprone Grave
- Ado-trastuzumab + Deferiprone Grave
- Aldesleukin + Deferiprone Grave
Outras interações de Vorinostat
- Thioridazine + Vorinostat Contraindicada
- Amiodarone + Vorinostat Grave
- Amisulpride + Vorinostat Grave
- Anagrelide + Vorinostat Grave
- Asenapine + Vorinostat Grave
- Chlorpromazine + Vorinostat Grave
Perguntas frequentes
Can I take Deferiprone with Vorinostat?
MediHelp rates the interaction as major. Deferiprone and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferiprone can cause agranulocytosis and neutropenia, and vorinostat commonly causes cytopenias, particularly thrombocytopenia and sometimes neutropenia. Combined use may increase the risk of severe bone marrow suppression and infection.
How serious is the interaction between Deferiprone and Vorinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if an alternative is available. If unavoidable, monitor absolute neutrophil count and platelets frequently and stop deferiprone if neutropenia occurs.
What other medicines interact with Deferiprone?
MediHelp also lists interactions of Deferiprone with, for example, Clozapine, Abemaciclib, Acalabrutinib. The full list is on the Deferiprone page.
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