Interações medicamentosas
Desloratadine + Erdafitinib
Gravidade: Moderada
Desloratadine and Erdafitinib: moderate interaction.
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Resumo
Erdafitinib inhibits P-glycoprotein and may raise exposure to P-gp substrates such as desloratadine. Because desloratadine has a wide therapeutic margin, the clinical consequence is usually limited.
O que esta interação significa em palavras simples
Desloratadine and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desloratadine belongs to Respiratory; Erdafitinib belongs to Oncology.
Por que acontece
Inhibition of intestinal and cellular P-glycoprotein efflux by erdafitinib increases desloratadine absorption.
O que fazer
Monitor for antihistamine adverse effects such as drowsiness or palpitations. Separating doses by at least 6 hours is a reasonable measure if concern exists.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Desloratadine
- Desloratadine + Isocarboxazid Moderada
- Desloratadine + Tranylcypromine Moderada
- Desloratadine + Zuranolone Moderada
- Amifampridine + Desloratadine Leve
- Berotralstat + Desloratadine Leve
- Bosutinib + Desloratadine Leve
Outras interações de Erdafitinib
Perguntas frequentes
Can I take Desloratadine with Erdafitinib?
MediHelp rates the interaction as moderate. Desloratadine and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits P-glycoprotein and may raise exposure to P-gp substrates such as desloratadine. Because desloratadine has a wide therapeutic margin, the clinical consequence is usually limited.
How serious is the interaction between Desloratadine and Erdafitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for antihistamine adverse effects such as drowsiness or palpitations. Separating doses by at least 6 hours is a reasonable measure if concern exists.
What other medicines interact with Desloratadine?
MediHelp also lists interactions of Desloratadine with, for example, Isocarboxazid, Tranylcypromine, Zuranolone. The full list is on the Desloratadine page.
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