Interações medicamentosas
Desloratadine + Isocarboxazid
Gravidade: Moderada
Desloratadine and Isocarboxazid: moderate interaction.
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Resumo
MAO inhibitors may intensify and prolong the anticholinergic and sedative effects of antihistamines. Desloratadine is non-sedating at usual doses, so the effect is generally mild.
O que esta interação significa em palavras simples
Desloratadine and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desloratadine belongs to Respiratory; Isocarboxazid belongs to Central Nervous System.
Por que acontece
Additive pharmacodynamic CNS depression, with MAO inhibition possibly potentiating antihistamine anticholinergic effects.
O que fazer
Monitor for drowsiness and anticholinergic symptoms such as dry mouth or urinary retention. Advise caution with driving until the response is known.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Desloratadine
- Desloratadine + Erdafitinib Moderada
- Desloratadine + Tranylcypromine Moderada
- Desloratadine + Zuranolone Moderada
- Amifampridine + Desloratadine Leve
- Berotralstat + Desloratadine Leve
- Bosutinib + Desloratadine Leve
Outras interações de Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicada
- Amitriptyline + Isocarboxazid Contraindicada
- Amobarbital + Isocarboxazid Contraindicada
- Amoxapine + Isocarboxazid Contraindicada
- Apraclonidine + Isocarboxazid Contraindicada
- Atomoxetine + Isocarboxazid Contraindicada
Perguntas frequentes
Can I take Desloratadine with Isocarboxazid?
MediHelp rates the interaction as moderate. Desloratadine and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors may intensify and prolong the anticholinergic and sedative effects of antihistamines. Desloratadine is non-sedating at usual doses, so the effect is generally mild.
How serious is the interaction between Desloratadine and Isocarboxazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and anticholinergic symptoms such as dry mouth or urinary retention. Advise caution with driving until the response is known.
What other medicines interact with Desloratadine?
MediHelp also lists interactions of Desloratadine with, for example, Erdafitinib, Tranylcypromine, Zuranolone. The full list is on the Desloratadine page.
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