Interações medicamentosas
Dexamethasone + Mifepristone
Gravidade: Contraindicada
Dexamethasone and Mifepristone: contraindicated interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Mifepristone is a glucocorticoid receptor antagonist, so it can block the effect of dexamethasone and precipitate adrenal insufficiency in patients who depend on corticosteroid therapy. Reduced corticosteroid effect may also worsen the underlying condition being treated.
O que esta interação significa em palavras simples
Dexamethasone and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dexamethasone belongs to Endocrine; Mifepristone belongs to Endocrine.
Por que acontece
Glucocorticoid receptor antagonism by mifepristone opposes corticosteroid effect
O que fazer
Mifepristone labelling contraindicates it in patients on long-term corticosteroids; avoid, or use an alternative route and monitor for adrenal insufficiency symptoms.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicada
- Dexamethasone + Rilpivirine Contraindicada
- Dexamethasone + Smallpox vaccine live Contraindicada
- Dexamethasone + Varicella virus vaccine live Contraindicada
- Dexamethasone + Yellow fever vaccine Contraindicada
- Dexamethasone + Zoster vaccine live Contraindicada
Outras interações de Mifepristone
- Apixaban + Mifepristone Contraindicada
- Argatroban + Mifepristone Contraindicada
- Cisapride + Mifepristone Contraindicada
- Cortisone + Mifepristone Contraindicada
- Cyclosporin + Mifepristone Contraindicada
- Dabigatran etexilate + Mifepristone Contraindicada
Perguntas frequentes
Can I take Dexamethasone with Mifepristone?
MediHelp rates the interaction as contraindicated. Dexamethasone and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mifepristone is a glucocorticoid receptor antagonist, so it can block the effect of dexamethasone and precipitate adrenal insufficiency in patients who depend on corticosteroid therapy. Reduced corticosteroid effect may also worsen the underlying condition being treated.
How serious is the interaction between Dexamethasone and Mifepristone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Mifepristone labelling contraindicates it in patients on long-term corticosteroids; avoid, or use an alternative route and monitor for adrenal insufficiency symptoms.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Rilpivirine, Smallpox vaccine live. The full list is on the Dexamethasone page.
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