Interações medicamentosas
Dexlansoprazole + Infigratinib
Gravidade: Grave
Dexlansoprazole and Infigratinib: major interaction.
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Resumo
Infigratinib has pH-dependent solubility, so reduced gastric acidity lowers its absorption. Dexlansoprazole may decrease infigratinib exposure and weaken its anticancer effect.
O que esta interação significa em palavras simples
Dexlansoprazole and Infigratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Increased gastric pH reduces infigratinib solubility and absorption.
O que fazer
Avoid PPIs with infigratinib. If acid reduction is required, use a locally acting antacid separated from infigratinib by the interval stated in the labeling.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicada
- Dexlansoprazole + Rilpivirine Contraindicada
- Acalabrutinib + Dexlansoprazole Grave
- Atazanavir + Dexlansoprazole Grave
- Dacomitinib + Dexlansoprazole Grave
- Dasatinib + Dexlansoprazole Grave
Perguntas frequentes
Can I take Dexlansoprazole with Infigratinib?
MediHelp rates the interaction as major. Dexlansoprazole and Infigratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Infigratinib has pH-dependent solubility, so reduced gastric acidity lowers its absorption. Dexlansoprazole may decrease infigratinib exposure and weaken its anticancer effect.
How serious is the interaction between Dexlansoprazole and Infigratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with infigratinib. If acid reduction is required, use a locally acting antacid separated from infigratinib by the interval stated in the labeling.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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