Interações medicamentosas
Dolasetron + Thioridazine
Gravidade: Contraindicada
Dolasetron and Thioridazine: contraindicated interaction.
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Resumo
Thioridazine causes marked, dose-related QT prolongation and is itself associated with torsades de pointes. Adding dolasetron substantially increases the risk of fatal arrhythmia.
O que esta interação significa em palavras simples
Dolasetron and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dolasetron belongs to Gastrointestinal Tract; Thioridazine belongs to Central Nervous System.
Por que acontece
Additive potassium channel blockade producing marked QT prolongation.
O que fazer
Do not combine; choose an antiemetic from a class without QT effects such as a dopamine antagonist alternative with low risk. Thioridazine labeling advises against use with other QT-prolonging agents.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Dolasetron
- Apomorphine + Dolasetron Contraindicada
- Dofetilide + Dolasetron Contraindicada
- Dolasetron + Ibutilide Contraindicada
- Dolasetron + Pimozide Contraindicada
- Dolasetron + Vandetanib Contraindicada
- Dolasetron + Ziprasidone Contraindicada
Outras interações de Thioridazine
- Abiraterone + Thioridazine Contraindicada
- Adagrasib + Thioridazine Contraindicada
- Amiodarone + Thioridazine Contraindicada
- Amisulpride + Thioridazine Contraindicada
- Amitriptyline + Thioridazine Contraindicada
- Amoxapine + Thioridazine Contraindicada
Perguntas frequentes
Can I take Dolasetron with Thioridazine?
MediHelp rates the interaction as contraindicated. Dolasetron and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine causes marked, dose-related QT prolongation and is itself associated with torsades de pointes. Adding dolasetron substantially increases the risk of fatal arrhythmia.
How serious is the interaction between Dolasetron and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose an antiemetic from a class without QT effects such as a dopamine antagonist alternative with low risk. Thioridazine labeling advises against use with other QT-prolonging agents.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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