Interações medicamentosas
Dolasetron + Ziprasidone
Gravidade: Contraindicada
Dolasetron and Ziprasidone: contraindicated interaction.
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Resumo
Ziprasidone is among the antipsychotics with notable QT prolongation, and it is contraindicated with other QT-prolonging drugs. Combined with dolasetron the risk of torsades de pointes is increased.
O que esta interação significa em palavras simples
Dolasetron and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dolasetron belongs to Gastrointestinal Tract; Ziprasidone belongs to Central Nervous System.
Por que acontece
Additive blockade of cardiac repolarizing potassium currents causing QT prolongation.
O que fazer
Avoid the combination and use an antiemetic without QT effect. If an antiemetic is essential, consider a different agent and monitor ECG and electrolytes.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Dolasetron
- Apomorphine + Dolasetron Contraindicada
- Dofetilide + Dolasetron Contraindicada
- Dolasetron + Ibutilide Contraindicada
- Dolasetron + Pimozide Contraindicada
- Dolasetron + Thioridazine Contraindicada
- Dolasetron + Vandetanib Contraindicada
Outras interações de Ziprasidone
- Amiodarone + Ziprasidone Contraindicada
- Amitriptyline + Ziprasidone Contraindicada
- Arsenic trioxide + Ziprasidone Contraindicada
- Bedaquiline + Ziprasidone Contraindicada
- Chloroquine + Ziprasidone Contraindicada
- Citalopram + Ziprasidone Contraindicada
Perguntas frequentes
Can I take Dolasetron with Ziprasidone?
MediHelp rates the interaction as contraindicated. Dolasetron and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ziprasidone is among the antipsychotics with notable QT prolongation, and it is contraindicated with other QT-prolonging drugs. Combined with dolasetron the risk of torsades de pointes is increased.
How serious is the interaction between Dolasetron and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antiemetic without QT effect. If an antiemetic is essential, consider a different agent and monitor ECG and electrolytes.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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