Interações medicamentosas
Epirubicin + Trastuzumab deruxtecan
Gravidade: Grave
Epirubicin and Trastuzumab deruxtecan: major interaction.
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Resumo
Trastuzumab-based therapy can cause cardiomyopathy and left ventricular dysfunction, and the risk is highest when given with anthracyclines. Epirubicin adds its own dose-related cardiotoxicity, and trastuzumab deruxtecan also carries risk of interstitial lung disease and myelosuppression.
O que esta interação significa em palavras simples
Epirubicin and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Epirubicin belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Por que acontece
Additive cardiotoxicity from HER2 inhibition and anthracycline-induced myocardial injury.
O que fazer
Avoid concurrent use when possible and keep the interval between agents as long as practical. Check left ventricular ejection fraction before and during treatment.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Epirubicin
- Adenovirus types 4 and 7 live + Epirubicin Contraindicada
- Belatacept + Epirubicin Grave
- Cimetidine + Epirubicin Grave
- Deferiprone + Epirubicin Grave
- Dengue vaccine + Epirubicin Grave
- Epirubicin + Etrasimod Grave
Outras interações de Trastuzumab deruxtecan
Perguntas frequentes
Can I take Epirubicin with Trastuzumab deruxtecan?
MediHelp rates the interaction as major. Epirubicin and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab-based therapy can cause cardiomyopathy and left ventricular dysfunction, and the risk is highest when given with anthracyclines. Epirubicin adds its own dose-related cardiotoxicity, and trastuzumab deruxtecan also carries risk of interstitial lung disease and myelosuppression.
How serious is the interaction between Epirubicin and Trastuzumab deruxtecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when possible and keep the interval between agents as long as practical. Check left ventricular ejection fraction before and during treatment.
What other medicines interact with Epirubicin?
MediHelp also lists interactions of Epirubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cimetidine. The full list is on the Epirubicin page.
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