Interações medicamentosas
Ergotamine + Erythromycin lactobionate
Gravidade: Contraindicada
Ergotamine and Erythromycin lactobionate: contraindicated interaction.
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Resumo
Intravenous erythromycin markedly raises ergotamine exposure, and this has led to acute ergotism with severe vasospasm and ischemia. Ergotamine labeling contraindicates its use with macrolide antibiotics.
O que esta interação significa em palavras simples
Ergotamine and Erythromycin lactobionate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ergotamine belongs to Central Nervous System; Erythromycin lactobionate belongs to Anti Bacterial.
Por que acontece
Erythromycin inhibits CYP3A4-mediated metabolism of ergotamine, increasing its systemic concentrations.
O que fazer
Do not co-administer; withhold ergotamine while erythromycin is given or select a different antibiotic. Monitor for signs of peripheral ischemia if exposure occurs.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Ergotamine
- Almotriptan + Ergotamine Contraindicada
- Atazanavir + Ergotamine Contraindicada
- Clarithromycin + Ergotamine Contraindicada
- Cobicistat + Ergotamine Contraindicada
- Darunavir + Ergotamine Contraindicada
- Dihydroergotamine intranasal + Ergotamine Contraindicada
Outras interações de Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicada
- Dihydroergotamine + Erythromycin lactobionate Contraindicada
- Dronedarone + Erythromycin lactobionate Contraindicada
- Eletriptan + Erythromycin lactobionate Contraindicada
- Erythromycin lactobionate + Flibanserin Contraindicada
- Erythromycin lactobionate + Lovastatin Contraindicada
Perguntas frequentes
Can I take Ergotamine with Erythromycin lactobionate?
MediHelp rates the interaction as contraindicated. Ergotamine and Erythromycin lactobionate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Intravenous erythromycin markedly raises ergotamine exposure, and this has led to acute ergotism with severe vasospasm and ischemia. Ergotamine labeling contraindicates its use with macrolide antibiotics.
How serious is the interaction between Ergotamine and Erythromycin lactobionate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; withhold ergotamine while erythromycin is given or select a different antibiotic. Monitor for signs of peripheral ischemia if exposure occurs.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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