Interações medicamentosas
Dihydroergotamine + Erythromycin lactobionate
Gravidade: Contraindicada
Dihydroergotamine and Erythromycin lactobionate: contraindicated interaction.
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Resumo
Erythromycin raises dihydroergotamine concentrations, which can cause ergotism with severe peripheral and cerebral vasospasm and ischemia. Cases of limb and organ ischemia have been reported with CYP3A4 inhibitors and ergots.
O que esta interação significa em palavras simples
Dihydroergotamine and Erythromycin lactobionate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Erythromycin lactobionate belongs to Anti Bacterial.
Por que acontece
Erythromycin inhibits CYP3A4-mediated metabolism of dihydroergotamine.
O que fazer
Do not use together; choose a non-macrolide antibiotic such as one without CYP3A4 inhibition, or another migraine therapy.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicada
- Dronedarone + Erythromycin lactobionate Contraindicada
- Eletriptan + Erythromycin lactobionate Contraindicada
- Ergotamine + Erythromycin lactobionate Contraindicada
- Erythromycin lactobionate + Flibanserin Contraindicada
- Erythromycin lactobionate + Lovastatin Contraindicada
Outras interações de Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicada
- Clarithromycin + Dihydroergotamine Contraindicada
- Dihydroergotamine + Dopamine Contraindicada
- Dihydroergotamine + Dronedarone Contraindicada
- Dihydroergotamine + Efavirenz Contraindicada
- Dihydroergotamine + Eletriptan Contraindicada
Perguntas frequentes
Can I take Dihydroergotamine with Erythromycin lactobionate?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Erythromycin lactobionate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Erythromycin raises dihydroergotamine concentrations, which can cause ergotism with severe peripheral and cerebral vasospasm and ischemia. Cases of limb and organ ischemia have been reported with CYP3A4 inhibitors and ergots.
How serious is the interaction between Dihydroergotamine and Erythromycin lactobionate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose a non-macrolide antibiotic such as one without CYP3A4 inhibition, or another migraine therapy.
What other medicines interact with Erythromycin lactobionate?
MediHelp also lists interactions of Erythromycin lactobionate with, for example, Cisapride, Dronedarone, Eletriptan. The full list is on the Erythromycin lactobionate page.
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