Interações medicamentosas
Gefitinib + Rifampicin
Gravidade: Grave
Gefitinib and Rifampicin: major interaction.
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Resumo
Rifampicin markedly lowers gefitinib plasma concentrations through enzyme induction. Subtherapeutic exposure may lead to loss of tumour control.
O que esta interação significa em palavras simples
Gefitinib and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gefitinib belongs to Oncology; Rifampicin belongs to Anti Bacterial.
Por que acontece
Induction of CYP3A4 by rifampicin increases the metabolic clearance of gefitinib.
O que fazer
Avoid the combination if possible. If rifampicin is necessary, raise gefitinib to 500 mg daily as per labeling and return to 250 mg after the inducer has been stopped for about 7 days.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Gefitinib
Outras interações de Rifampicin
- Cabotegravir + Rifampicin Contraindicada
- Delamanid + Rifampicin Contraindicada
- Doravirine + Rifampicin Contraindicada
- Ensitrelvir + Rifampicin Contraindicada
- Fostemsavir + Rifampicin Contraindicada
- Isavuconazole + Rifampicin Contraindicada
Perguntas frequentes
Can I take Gefitinib with Rifampicin?
MediHelp rates the interaction as major. Gefitinib and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin markedly lowers gefitinib plasma concentrations through enzyme induction. Subtherapeutic exposure may lead to loss of tumour control.
How serious is the interaction between Gefitinib and Rifampicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If rifampicin is necessary, raise gefitinib to 500 mg daily as per labeling and return to 250 mg after the inducer has been stopped for about 7 days.
What other medicines interact with Gefitinib?
MediHelp also lists interactions of Gefitinib with, for example, Apalutamide, Carbamazepine, Dexlansoprazole. The full list is on the Gefitinib page.
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