Interações medicamentosas
Esomeprazole + Gefitinib
Gravidade: Grave
Esomeprazole and Gefitinib: major interaction.
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Resumo
Gefitinib solubility falls as gastric pH rises, and PPIs can markedly lower gefitinib exposure. This may reduce anticancer efficacy.
O que esta interação significa em palavras simples
Esomeprazole and Gefitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Esomeprazole belongs to Gastrointestinal Tract; Gefitinib belongs to Oncology.
Por que acontece
Sustained increases in gastric pH reduce gefitinib dissolution and absorption.
O que fazer
Avoid concomitant PPI use if possible; if a PPI is essential, give gefitinib 12 hours after the PPI dose and consider an alternative acid reducer.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Esomeprazole
- Esomeprazole + Mavacamten Contraindicada
- Esomeprazole + Rilpivirine Contraindicada
- Acalabrutinib + Esomeprazole Grave
- Atazanavir + Esomeprazole Grave
- Citalopram + Esomeprazole Grave
- Clopidogrel + Esomeprazole Grave
Outras interações de Gefitinib
Perguntas frequentes
Can I take Esomeprazole with Gefitinib?
MediHelp rates the interaction as major. Esomeprazole and Gefitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gefitinib solubility falls as gastric pH rises, and PPIs can markedly lower gefitinib exposure. This may reduce anticancer efficacy.
How serious is the interaction between Esomeprazole and Gefitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant PPI use if possible; if a PPI is essential, give gefitinib 12 hours after the PPI dose and consider an alternative acid reducer.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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