Interações medicamentosas
Gefitinib + Omeprazole
Gravidade: Grave
Gefitinib and Omeprazole: major interaction.
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Resumo
Gefitinib absorption depends on gastric acidity, and raising gastric pH substantially lowers its exposure. This may reduce anti-tumour efficacy.
O que esta interação significa em palavras simples
Gefitinib and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gefitinib belongs to Oncology; Omeprazole belongs to Gastrointestinal Tract.
Por que acontece
Omeprazole raises gastric pH, decreasing gefitinib solubility and absorption.
O que fazer
Avoid PPIs if possible. If one is needed, take gefitinib 12 hours after the PPI dose, though H2 antagonists or antacids with timed separation are preferable.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Gefitinib
Perguntas frequentes
Can I take Gefitinib with Omeprazole?
MediHelp rates the interaction as major. Gefitinib and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gefitinib absorption depends on gastric acidity, and raising gastric pH substantially lowers its exposure. This may reduce anti-tumour efficacy.
How serious is the interaction between Gefitinib and Omeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs if possible. If one is needed, take gefitinib 12 hours after the PPI dose, though H2 antagonists or antacids with timed separation are preferable.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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