Interações medicamentosas
Gefitinib + Lansoprazole
Gravidade: Grave
Gefitinib and Lansoprazole: major interaction.
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Resumo
Gefitinib needs an acidic stomach for adequate dissolution, and sustained gastric pH elevation lowers gefitinib exposure. This may compromise its efficacy in EGFR-mutant lung cancer.
O que esta interação significa em palavras simples
Gefitinib and Lansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gefitinib belongs to Oncology; Lansoprazole belongs to Gastrointestinal Tract.
Por que acontece
Gastric pH elevation reduces gefitinib solubility and absorption.
O que fazer
Avoid PPIs if possible. If a PPI is essential, give gefitinib 12 hours after the PPI dose, though acid-reducing effects may persist.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Lansoprazole
- Lansoprazole + Mavacamten Contraindicada
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- Acalabrutinib + Lansoprazole Grave
- Atazanavir + Lansoprazole Grave
- Dacomitinib + Lansoprazole Grave
- Dasatinib + Lansoprazole Grave
Outras interações de Gefitinib
Perguntas frequentes
Can I take Gefitinib with Lansoprazole?
MediHelp rates the interaction as major. Gefitinib and Lansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gefitinib needs an acidic stomach for adequate dissolution, and sustained gastric pH elevation lowers gefitinib exposure. This may compromise its efficacy in EGFR-mutant lung cancer.
How serious is the interaction between Gefitinib and Lansoprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs if possible. If a PPI is essential, give gefitinib 12 hours after the PPI dose, though acid-reducing effects may persist.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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