Interações medicamentosas
Dexlansoprazole + Gefitinib
Gravidade: Grave
Dexlansoprazole and Gefitinib: major interaction.
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Resumo
Gefitinib needs an acidic stomach for adequate absorption, and acid suppression with a PPI lowers its exposure markedly. This may reduce anticancer efficacy.
O que esta interação significa em palavras simples
Dexlansoprazole and Gefitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexlansoprazole belongs to Gastrointestinal Tract; Gefitinib belongs to Oncology.
Por que acontece
Increased gastric pH reduces gefitinib solubility and absorption.
O que fazer
Avoid PPIs if possible. If one is required, take gefitinib 12 hours after the PPI dose, though this may not fully prevent the effect.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicada
- Dexlansoprazole + Rilpivirine Contraindicada
- Acalabrutinib + Dexlansoprazole Grave
- Atazanavir + Dexlansoprazole Grave
- Dacomitinib + Dexlansoprazole Grave
- Dasatinib + Dexlansoprazole Grave
Outras interações de Gefitinib
- Apalutamide + Gefitinib Grave
- Carbamazepine + Gefitinib Grave
- Esomeprazole + Gefitinib Grave
- Gefitinib + Lansoprazole Grave
- Gefitinib + Omeprazole Grave
- Gefitinib + Pantoprazole Grave
Perguntas frequentes
Can I take Dexlansoprazole with Gefitinib?
MediHelp rates the interaction as major. Dexlansoprazole and Gefitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gefitinib needs an acidic stomach for adequate absorption, and acid suppression with a PPI lowers its exposure markedly. This may reduce anticancer efficacy.
How serious is the interaction between Dexlansoprazole and Gefitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs if possible. If one is required, take gefitinib 12 hours after the PPI dose, though this may not fully prevent the effect.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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