Interações medicamentosas
Gliclazide + Sulfamethoxazole
Gravidade: Grave
Gliclazide and Sulfamethoxazole: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Sulfamethoxazole, usually given as co-trimoxazole, can enhance the glucose-lowering effect of sulfonylureas and has been linked to serious hypoglycemia. Elderly patients and those with kidney disease are particularly vulnerable.
O que esta interação significa em palavras simples
Gliclazide and Sulfamethoxazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Sulfamethoxazole inhibits CYP2C9, which metabolizes the sulfonylurea, and may displace it from protein binding.
O que fazer
Monitor blood glucose closely, particularly in the first days of therapy, and lower the gliclazide dose if needed; consider an alternative antibiotic in high-risk patients.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Gliclazide e Sulfamethoxazole, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Gliclazide
Perguntas frequentes
Can I take Gliclazide with Sulfamethoxazole?
MediHelp rates the interaction as major. Gliclazide and Sulfamethoxazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sulfamethoxazole, usually given as co-trimoxazole, can enhance the glucose-lowering effect of sulfonylureas and has been linked to serious hypoglycemia. Elderly patients and those with kidney disease are particularly vulnerable.
How serious is the interaction between Gliclazide and Sulfamethoxazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely, particularly in the first days of therapy, and lower the gliclazide dose if needed; consider an alternative antibiotic in high-risk patients.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
