Interações medicamentosas
Gliclazide + Voriconazole
Gravidade: Grave
Gliclazide and Voriconazole: major interaction.
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Resumo
Voriconazole can raise gliclazide concentrations, increasing the risk of prolonged or severe hypoglycemia. Gliclazide is cleared by CYP2C9 and CYP2C19, both inhibited by voriconazole.
O que esta interação significa em palavras simples
Gliclazide and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gliclazide belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Por que acontece
Voriconazole inhibits CYP2C9 and CYP2C19, reducing gliclazide metabolism.
O que fazer
Monitor blood glucose closely and consider reducing the gliclazide dose during voriconazole therapy. Re-adjust after voriconazole is stopped.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Gliclazide
Outras interações de Voriconazole
- Avanafil + Voriconazole Contraindicada
- Butabarbital + Voriconazole Contraindicada
- Carbamazepine + Voriconazole Contraindicada
- Conivaptan + Voriconazole Contraindicada
- Dihydroergotamine intranasal + Voriconazole Contraindicada
- Dihydroergotamine + Voriconazole Contraindicada
Perguntas frequentes
Can I take Gliclazide with Voriconazole?
MediHelp rates the interaction as major. Gliclazide and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole can raise gliclazide concentrations, increasing the risk of prolonged or severe hypoglycemia. Gliclazide is cleared by CYP2C9 and CYP2C19, both inhibited by voriconazole.
How serious is the interaction between Gliclazide and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and consider reducing the gliclazide dose during voriconazole therapy. Re-adjust after voriconazole is stopped.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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