Interações medicamentosas
Fluconazole + Gliclazide
Gravidade: Grave
Fluconazole and Gliclazide: major interaction.
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Resumo
Fluconazole raises gliclazide exposure and can cause prolonged or severe hypoglycemia. Cases of hypoglycemia have been reported with azole antifungals and sulfonylureas.
O que esta interação significa em palavras simples
Fluconazole and Gliclazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Gliclazide belongs to Endocrine.
Por que acontece
Fluconazole inhibits CYP2C9 and CYP2C19, which metabolize gliclazide, reducing its clearance.
O que fazer
Monitor blood glucose closely and reduce the gliclazide dose during fluconazole therapy. Consider an alternative antifungal if glycemic control is difficult.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Gliclazide
Outras interações de Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicada
- Dihydroergotamine + Fluconazole Contraindicada
- Dofetilide + Fluconazole Contraindicada
- Dronedarone + Fluconazole Contraindicada
- Erythromycin + Fluconazole Contraindicada
- Flibanserin + Fluconazole Contraindicada
Perguntas frequentes
Can I take Fluconazole with Gliclazide?
MediHelp rates the interaction as major. Fluconazole and Gliclazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole raises gliclazide exposure and can cause prolonged or severe hypoglycemia. Cases of hypoglycemia have been reported with azole antifungals and sulfonylureas.
How serious is the interaction between Fluconazole and Gliclazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the gliclazide dose during fluconazole therapy. Consider an alternative antifungal if glycemic control is difficult.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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