Interações medicamentosas
Clarithromycin + Gliclazide
Gravidade: Grave
Clarithromycin and Gliclazide: major interaction.
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Resumo
Clarithromycin has been associated with hypoglycemia in patients taking sulfonylureas, sometimes severe. Elderly patients and those with renal impairment are particularly vulnerable.
O que esta interação significa em palavras simples
Clarithromycin and Gliclazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Gliclazide belongs to Endocrine.
Por que acontece
Clarithromycin may raise sulfonylurea exposure by inhibiting metabolism and may stimulate insulin release; the exact mechanism is incompletely defined.
O que fazer
Monitor blood glucose closely, or choose a non-macrolide antibiotic where possible. Reduce the gliclazide dose if the combination is essential.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Gliclazide
Outras interações de Clarithromycin
- Astemizole + Clarithromycin Contraindicada
- Avanafil + Clarithromycin Contraindicada
- Cisapride + Clarithromycin Contraindicada
- Clarithromycin + Colchicine Contraindicada
- Clarithromycin + Conivaptan Contraindicada
- Clarithromycin + Dihydroergotamine Contraindicada
Perguntas frequentes
Can I take Clarithromycin with Gliclazide?
MediHelp rates the interaction as major. Clarithromycin and Gliclazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin has been associated with hypoglycemia in patients taking sulfonylureas, sometimes severe. Elderly patients and those with renal impairment are particularly vulnerable.
How serious is the interaction between Clarithromycin and Gliclazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely, or choose a non-macrolide antibiotic where possible. Reduce the gliclazide dose if the combination is essential.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Disopyramide, Fluconazole. The full list is on the Gliclazide page.
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