Interações medicamentosas
Glycerol phenylbutyrate + Haloperidol
Gravidade: Moderada
Glycerol phenylbutyrate and Haloperidol: moderate interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Glycerol phenylbutyrate is used to lower ammonia in urea cycle disorders, and haloperidol has been reported to raise ammonia levels. This may reduce disease control and risk hyperammonemic episodes.
O que esta interação significa em palavras simples
Glycerol phenylbutyrate and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycerol phenylbutyrate belongs to Miscellaneous; Haloperidol belongs to Central Nervous System.
Por que acontece
Haloperidol may increase blood ammonia, opposing the nitrogen-scavenging effect of glycerol phenylbutyrate; the mechanism is not fully established.
O que fazer
Monitor plasma ammonia closely when haloperidol is started or adjusted, and adjust the phenylbutyrate dose as indicated. Consider an alternative antipsychotic if ammonia control worsens.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Glycerol phenylbutyrate e Haloperidol, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Haloperidol
- Dofetilide + Haloperidol Contraindicada
- Dronedarone + Haloperidol Contraindicada
- Haloperidol + Ibutilide Contraindicada
- Haloperidol + Levoketoconazole Contraindicada
- Haloperidol + Panobinostat Contraindicada
- Haloperidol + Pimozide Contraindicada
Outras interações de Glycerol phenylbutyrate
- Dexamethasone + Glycerol phenylbutyrate Grave
- Glycerol phenylbutyrate + Valproic acid Grave
- Cyclosporin + Glycerol phenylbutyrate Moderada
- Dexamethasone-neomycin-polymyxin + Glycerol phenylbutyrate Moderada
- Dexamethasone-tobramycin + Glycerol phenylbutyrate Moderada
- Fludrocortisone + Glycerol phenylbutyrate Moderada
Perguntas frequentes
Can I take Glycerol phenylbutyrate with Haloperidol?
MediHelp rates the interaction as moderate. Glycerol phenylbutyrate and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glycerol phenylbutyrate is used to lower ammonia in urea cycle disorders, and haloperidol has been reported to raise ammonia levels. This may reduce disease control and risk hyperammonemic episodes.
How serious is the interaction between Glycerol phenylbutyrate and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely when haloperidol is started or adjusted, and adjust the phenylbutyrate dose as indicated. Consider an alternative antipsychotic if ammonia control worsens.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
