Interações medicamentosas
Irinotecan + Trastuzumab deruxtecan
Gravidade: Grave
Irinotecan and Trastuzumab deruxtecan: major interaction.
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Resumo
Trastuzumab deruxtecan carries a topoisomerase I inhibitor payload and causes neutropenia, while irinotecan is also myelosuppressive. Combined use may add hematologic toxicity, diarrhea and infection risk.
O que esta interação significa em palavras simples
Irinotecan and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Irinotecan belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Por que acontece
Additive myelosuppression and gastrointestinal toxicity from two topoisomerase I inhibitor exposures.
O que fazer
Avoid routine concurrent use; if combined, monitor complete blood counts frequently and reduce doses or delay treatment for neutropenia.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Irinotecan
- Clozapine + Irinotecan Contraindicada
- Irinotecan + Sacituzumab govitecan Contraindicada
- Adenovirus types 4 and 7 live + Irinotecan Grave
- Apalutamide + Irinotecan Grave
- Atazanavir + Irinotecan Grave
- Carbamazepine + Irinotecan Grave
Outras interações de Trastuzumab deruxtecan
Perguntas frequentes
Can I take Irinotecan with Trastuzumab deruxtecan?
MediHelp rates the interaction as major. Irinotecan and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab deruxtecan carries a topoisomerase I inhibitor payload and causes neutropenia, while irinotecan is also myelosuppressive. Combined use may add hematologic toxicity, diarrhea and infection risk.
How serious is the interaction between Irinotecan and Trastuzumab deruxtecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use; if combined, monitor complete blood counts frequently and reduce doses or delay treatment for neutropenia.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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