Interações medicamentosas
Isosorbide mononitrate + Tadalafil
Gravidade: Contraindicada
Isosorbide mononitrate and Tadalafil: contraindicated interaction.
Última atualização Fontes: US FDA label
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Resumo
Tadalafil markedly potentiates the hypotensive effect of nitrates, which can cause severe, potentially life-threatening hypotension, syncope or myocardial ischaemia. The effect persists for a prolonged period because of tadalafil's long half-life. Nitrates in any form are contraindicated with tadalafil.
O que esta interação significa em palavras simples
Isosorbide mononitrate and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isosorbide mononitrate belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Por que acontece
Nitrates increase cGMP by nitric oxide release while tadalafil inhibits PDE5-mediated cGMP breakdown, causing excessive vasodilation.
O que fazer
Do not coadminister. Nitrates should not be given within at least 48 hours after tadalafil, and in emergencies the decision should be under close medical supervision.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Referências
- Cialis (tadalafil) Prescribing Information - Contraindications — FDA Label
- Cialis SmPC - Contraindications — EMA SmPC
Outras interações de Tadalafil
- Amyl nitrite + Tadalafil Contraindicada
- Isosorbide dinitrate + Tadalafil Contraindicada
- Nitroglycerin po + Tadalafil Contraindicada
- Nitroglycerin rectal + Tadalafil Contraindicada
- Nitroglycerin sublingual + Tadalafil Contraindicada
- Nitroglycerin transdermal + Tadalafil Contraindicada
Outras interações de Isosorbide mononitrate
- Avanafil + Isosorbide mononitrate Contraindicada
- Isosorbide mononitrate + Riociguat Contraindicada
- Isosorbide mononitrate + Sildenafil Contraindicada
- Isosorbide mononitrate + Vardenafil Contraindicada
- Ergotamine + Isosorbide mononitrate Grave
- Isosorbide mononitrate + Methylergonovine Grave
Perguntas frequentes
Can I take Isosorbide mononitrate with Tadalafil?
MediHelp rates the interaction as contraindicated. Isosorbide mononitrate and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tadalafil markedly potentiates the hypotensive effect of nitrates, which can cause severe, potentially life-threatening hypotension, syncope or myocardial ischaemia. The effect persists for a prolonged period because of tadalafil's long half-life. Nitrates in any form are contraindicated with tadalafil.
How serious is the interaction between Isosorbide mononitrate and Tadalafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Nitrates should not be given within at least 48 hours after tadalafil, and in emergencies the decision should be under close medical supervision.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Nitroglycerin po. The full list is on the Tadalafil page.
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