Interações medicamentosas
Itraconazole + Rifaximin
Gravidade: Moderada
Itraconazole and Rifaximin: moderate interaction.
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Resumo
Itraconazole is a strong P-glycoprotein inhibitor and can raise systemic rifaximin exposure. The effect is generally modest but may be more relevant in severe liver disease.
O que esta interação significa em palavras simples
Itraconazole and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Rifaximin belongs to Anti Bacterial.
Por que acontece
P-glycoprotein inhibition by itraconazole reduces intestinal efflux of rifaximin.
O que fazer
Use usual rifaximin doses and monitor for adverse effects; be especially watchful in patients with Child-Pugh C disease.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Rifaximin
- Cholera vaccine + Rifaximin Grave
- Microbiota + Rifaximin Grave
- Amiodarone + Rifaximin Moderada
- Bcg intravesical live + Rifaximin Moderada
- Cyclosporine + Rifaximin Moderada
- Cyclosporin + Rifaximin Moderada
Outras interações de Itraconazole
- Alfuzosin + Itraconazole Contraindicada
- Alprazolam + Itraconazole Contraindicada
- Avanafil + Itraconazole Contraindicada
- Conivaptan + Itraconazole Contraindicada
- Dihydroergotamine intranasal + Itraconazole Contraindicada
- Dihydroergotamine + Itraconazole Contraindicada
Perguntas frequentes
Can I take Itraconazole with Rifaximin?
MediHelp rates the interaction as moderate. Itraconazole and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole is a strong P-glycoprotein inhibitor and can raise systemic rifaximin exposure. The effect is generally modest but may be more relevant in severe liver disease.
How serious is the interaction between Itraconazole and Rifaximin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use usual rifaximin doses and monitor for adverse effects; be especially watchful in patients with Child-Pugh C disease.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
Monografias completas, posologia e verificador de interações no app MediHelp
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