Interações medicamentosas
Lidocaine + Pefloxacin
Gravidade: Moderada
Lidocaine and Pefloxacin: moderate interaction.
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Resumo
Fluoroquinolones that inhibit CYP1A2 can reduce lidocaine clearance and raise its concentrations. Pefloxacin is a CYP1A2 inhibitor and this may lead to lidocaine toxicity with systemic or repeated dosing.
O que esta interação significa em palavras simples
Lidocaine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lidocaine belongs to Cardiovascular; Pefloxacin belongs to Anti Bacterial.
Por que acontece
Inhibition of CYP1A2-mediated lidocaine metabolism reduces clearance.
O que fazer
With systemic lidocaine infusion, monitor for signs of toxicity and consider dose reduction; no change is usually needed for single local anesthetic doses.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Lidocaine
- Bupivacaine liposome + Lidocaine Grave
- Disopyramide + Lidocaine Grave
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Grave
- Lidocaine + Nirmatrelvir / ritonavir Grave
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Grave
- Lidocaine + Pimozide Grave
Outras interações de Pefloxacin
- Pefloxacin + Tizanidine Contraindicada
- Clozapine + Pefloxacin Grave
- Duloxetine + Pefloxacin Grave
- Pefloxacin + Theophylline Grave
- Asenapine + Pefloxacin Moderada
- Caffeine + Pefloxacin Moderada
Perguntas frequentes
Can I take Lidocaine with Pefloxacin?
MediHelp rates the interaction as moderate. Lidocaine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones that inhibit CYP1A2 can reduce lidocaine clearance and raise its concentrations. Pefloxacin is a CYP1A2 inhibitor and this may lead to lidocaine toxicity with systemic or repeated dosing.
How serious is the interaction between Lidocaine and Pefloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic lidocaine infusion, monitor for signs of toxicity and consider dose reduction; no change is usually needed for single local anesthetic doses.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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