Interações medicamentosas
Linezolid + Naratriptan
Gravidade: Grave
Linezolid and Naratriptan: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Linezolid's MAO-inhibiting activity combined with a triptan raises the risk of serotonin syndrome. Naratriptan is not mainly metabolized by MAO, so its exposure rise is limited, but the serotonergic concern remains.
O que esta interação significa em palavras simples
Linezolid and Naratriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Linezolid belongs to Anti Bacterial; Naratriptan belongs to Central Nervous System.
Por que acontece
Additive serotonergic effect from MAO inhibition and 5-HT1B/1D agonism.
O que fazer
Avoid the combination where possible and use non-serotonergic acute migraine treatment during linezolid therapy; if used together, monitor for agitation, tremor, hyperthermia and clonus.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Linezolid
- Amoxapine + Linezolid Contraindicada
- Atomoxetine + Linezolid Contraindicada
- Benzphetamine + Linezolid Contraindicada
- Brimonidine + Linezolid Contraindicada
- Bupropion-naltrexone + Linezolid Contraindicada
- Bupropion + Linezolid Contraindicada
Outras interações de Naratriptan
- Almotriptan + Naratriptan Contraindicada
- Dihydroergotamine intranasal + Naratriptan Contraindicada
- Dihydroergotamine + Naratriptan Contraindicada
- Eletriptan + Naratriptan Contraindicada
- Ergoloid mesylates + Naratriptan Contraindicada
- Ergotamine + Naratriptan Contraindicada
Perguntas frequentes
Can I take Linezolid with Naratriptan?
MediHelp rates the interaction as major. Linezolid and Naratriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Linezolid's MAO-inhibiting activity combined with a triptan raises the risk of serotonin syndrome. Naratriptan is not mainly metabolized by MAO, so its exposure rise is limited, but the serotonergic concern remains.
How serious is the interaction between Linezolid and Naratriptan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use non-serotonergic acute migraine treatment during linezolid therapy; if used together, monitor for agitation, tremor, hyperthermia and clonus.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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