Interações medicamentosas
Maprotiline + Methylene blue
Gravidade: Contraindicada
Maprotiline and Methylene blue: contraindicated interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Methylene blue inhibits monoamine oxidase A, so combining it with a serotonergic antidepressant can cause serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability. The reaction can be severe.
O que esta interação significa em palavras simples
Maprotiline and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
MAO-A inhibition by methylene blue combined with maprotiline's norepinephrine reuptake blockade increases monoamine activity.
O que fazer
Avoid unless urgent treatment is essential; if needed, stop maprotiline and monitor for CNS toxicity. Serotonergic therapy can be resumed 24 hours after the last methylene blue dose, or sooner if toxicity is absent after 2 weeks of monitoring.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Maprotiline e Methylene blue, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Maprotiline
- Arsenic trioxide + Maprotiline Contraindicada
- Disopyramide + Maprotiline Contraindicada
- Dofetilide + Maprotiline Contraindicada
- Ibutilide + Maprotiline Contraindicada
- Isocarboxazid + Maprotiline Contraindicada
- Maprotiline + Phenelzine Contraindicada
Perguntas frequentes
Can I take Maprotiline with Methylene blue?
MediHelp rates the interaction as contraindicated. Maprotiline and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylene blue inhibits monoamine oxidase A, so combining it with a serotonergic antidepressant can cause serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability. The reaction can be severe.
How serious is the interaction between Maprotiline and Methylene blue?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless urgent treatment is essential; if needed, stop maprotiline and monitor for CNS toxicity. Serotonergic therapy can be resumed 24 hours after the last methylene blue dose, or sooner if toxicity is absent after 2 weeks of monitoring.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
