Interações medicamentosas
Arsenic trioxide + Maprotiline
Gravidade: Contraindicada
Arsenic trioxide and Maprotiline: contraindicated interaction.
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Resumo
Arsenic trioxide causes marked QT prolongation and torsades de pointes, and maprotiline adds to this risk. The combination can cause life-threatening ventricular arrhythmias.
O que esta interação significa em palavras simples
Arsenic trioxide and Maprotiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Arsenic trioxide belongs to Oncology; Maprotiline belongs to Central Nervous System.
Por que acontece
Additive QT prolongation through cardiac repolarization effects.
O que fazer
Avoid the combination and use a non-QT-prolonging antidepressant during arsenic trioxide therapy. If it is unavoidable, perform continuous ECG monitoring and keep potassium and magnesium replete.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Maprotiline
- Disopyramide + Maprotiline Contraindicada
- Dofetilide + Maprotiline Contraindicada
- Ibutilide + Maprotiline Contraindicada
- Isocarboxazid + Maprotiline Contraindicada
- Maprotiline + Methylene blue Contraindicada
- Maprotiline + Phenelzine Contraindicada
Outras interações de Arsenic trioxide
- Amiodarone + Arsenic trioxide Contraindicada
- Amisulpride + Arsenic trioxide Contraindicada
- Arsenic trioxide + Clomipramine Contraindicada
- Arsenic trioxide + Dronedarone Contraindicada
- Arsenic trioxide + Fluphenazine Contraindicada
- Arsenic trioxide + Gemifloxacin Contraindicada
Perguntas frequentes
Can I take Arsenic trioxide with Maprotiline?
MediHelp rates the interaction as contraindicated. Arsenic trioxide and Maprotiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Arsenic trioxide causes marked QT prolongation and torsades de pointes, and maprotiline adds to this risk. The combination can cause life-threatening ventricular arrhythmias.
How serious is the interaction between Arsenic trioxide and Maprotiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-QT-prolonging antidepressant during arsenic trioxide therapy. If it is unavoidable, perform continuous ECG monitoring and keep potassium and magnesium replete.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Maprotiline page.
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