Interações medicamentosas
Isocarboxazid + Maprotiline
Gravidade: Contraindicada
Isocarboxazid and Maprotiline: contraindicated interaction.
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Resumo
Isocarboxazid irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and maprotiline is a tetracyclic antidepressant that blocks noradrenaline reuptake. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.
O que esta interação significa em palavras simples
Isocarboxazid and Maprotiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Por que acontece
Excess serotonergic activity (MAO inhibition plus serotonin reuptake or receptor effects)
O que fazer
Do not co-administer. Leave at least 14 days after stopping isocarboxazid before starting maprotiline, and at least 14 days after stopping maprotiline before starting isocarboxazid.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Maprotiline
- Arsenic trioxide + Maprotiline Contraindicada
- Disopyramide + Maprotiline Contraindicada
- Dofetilide + Maprotiline Contraindicada
- Ibutilide + Maprotiline Contraindicada
- Maprotiline + Methylene blue Contraindicada
- Maprotiline + Phenelzine Contraindicada
Outras interações de Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicada
- Amitriptyline + Isocarboxazid Contraindicada
- Amobarbital + Isocarboxazid Contraindicada
- Amoxapine + Isocarboxazid Contraindicada
- Apraclonidine + Isocarboxazid Contraindicada
- Atomoxetine + Isocarboxazid Contraindicada
Perguntas frequentes
Can I take Isocarboxazid with Maprotiline?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Maprotiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and maprotiline is a tetracyclic antidepressant that blocks noradrenaline reuptake. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.
How serious is the interaction between Isocarboxazid and Maprotiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Leave at least 14 days after stopping isocarboxazid before starting maprotiline, and at least 14 days after stopping maprotiline before starting isocarboxazid.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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