Interações medicamentosas
Maprotiline + Phenelzine
Gravidade: Contraindicada
Maprotiline and Phenelzine: contraindicated interaction.
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Resumo
Maprotiline, a noradrenergic tetracyclic, combined with the MAOI phenelzine can produce hypertensive crisis, serotonin-like toxicity and severe agitation. Serious reactions may occur.
O que esta interação significa em palavras simples
Maprotiline and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Maprotiline belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Por que acontece
MAO inhibition combined with norepinephrine reuptake blockade leads to excess monoamine activity.
O que fazer
Do not combine; allow at least 14 days after stopping phenelzine before maprotiline and an appropriate interval in reverse.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Maprotiline
- Arsenic trioxide + Maprotiline Contraindicada
- Disopyramide + Maprotiline Contraindicada
- Dofetilide + Maprotiline Contraindicada
- Ibutilide + Maprotiline Contraindicada
- Isocarboxazid + Maprotiline Contraindicada
- Maprotiline + Methylene blue Contraindicada
Outras interações de Phenelzine
- 5-HTP + Phenelzine Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amoxapine + Phenelzine Contraindicada
- Atomoxetine + Phenelzine Contraindicada
- Benzphetamine + Phenelzine Contraindicada
- Brimonidine + Phenelzine Contraindicada
Perguntas frequentes
Can I take Maprotiline with Phenelzine?
MediHelp rates the interaction as contraindicated. Maprotiline and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Maprotiline, a noradrenergic tetracyclic, combined with the MAOI phenelzine can produce hypertensive crisis, serotonin-like toxicity and severe agitation. Serious reactions may occur.
How serious is the interaction between Maprotiline and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping phenelzine before maprotiline and an appropriate interval in reverse.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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