Interações medicamentosas
Methadone + Sodium oxybate
Gravidade: Contraindicada
Methadone and Sodium oxybate: contraindicated interaction.
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Resumo
Both drugs depress the central nervous system, and together they can cause profound sedation, respiratory depression, coma and death. Sodium oxybate labeling warns against use with other CNS depressants.
O que esta interação significa em palavras simples
Methadone and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Methadone belongs to Musculoskeletal; Sodium oxybate belongs to Central Nervous System.
Por que acontece
Additive CNS and respiratory depression through pharmacodynamic synergism.
O que fazer
Avoid the combination; use alternative therapy for one of the drugs. If it is unavoidable, use the lowest doses for the shortest time and monitor closely for sedation and respiratory depression.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
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Outras interações de Methadone
- Alvimopan + Methadone Contraindicada
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicada
- Droperidol + Methadone Contraindicada
- Ibutilide + Methadone Contraindicada
- Isocarboxazid + Methadone Contraindicada
- Lefamulin + Methadone Contraindicada
Outras interações de Sodium oxybate
- Alprazolam + Sodium oxybate Contraindicada
- Amobarbital + Sodium oxybate Contraindicada
- Butorphanol + Sodium oxybate Contraindicada
- Chloral hydrate + Sodium oxybate Contraindicada
- Clonazepam + Sodium oxybate Contraindicada
- Clorazepate + Sodium oxybate Contraindicada
Perguntas frequentes
Can I take Methadone with Sodium oxybate?
MediHelp rates the interaction as contraindicated. Methadone and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs depress the central nervous system, and together they can cause profound sedation, respiratory depression, coma and death. Sodium oxybate labeling warns against use with other CNS depressants.
How serious is the interaction between Methadone and Sodium oxybate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use alternative therapy for one of the drugs. If it is unavoidable, use the lowest doses for the shortest time and monitor closely for sedation and respiratory depression.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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