Interações medicamentosas
Nitroglycerin rectal + Tadalafil
Gravidade: Contraindicada
Nitroglycerin rectal and Tadalafil: contraindicated interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Tadalafil markedly enhances the blood pressure lowering effect of rectal nitroglycerin. Severe hypotension may occur and the risk lasts well beyond the dose because of tadalafil's long half-life.
O que esta interação significa em palavras simples
Nitroglycerin rectal and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Additive cGMP-mediated vasodilation from nitric oxide donation and PDE5 inhibition.
O que fazer
Avoid combination; keep nitrates at least 48 hours away from tadalafil. Use non-nitrate therapy within that window.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Nitroglycerin rectal e Tadalafil, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Tadalafil
- Amyl nitrite + Tadalafil Contraindicada
- Isosorbide dinitrate + Tadalafil Contraindicada
- Isosorbide mononitrate + Tadalafil Contraindicada
- Nitroglycerin po + Tadalafil Contraindicada
- Nitroglycerin sublingual + Tadalafil Contraindicada
- Nitroglycerin transdermal + Tadalafil Contraindicada
Perguntas frequentes
Can I take Nitroglycerin rectal with Tadalafil?
MediHelp rates the interaction as contraindicated. Nitroglycerin rectal and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tadalafil markedly enhances the blood pressure lowering effect of rectal nitroglycerin. Severe hypotension may occur and the risk lasts well beyond the dose because of tadalafil's long half-life.
How serious is the interaction between Nitroglycerin rectal and Tadalafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination; keep nitrates at least 48 hours away from tadalafil. Use non-nitrate therapy within that window.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
