Interações medicamentosas
Amyl nitrite + Tadalafil
Gravidade: Contraindicada
Amyl nitrite and Tadalafil: contraindicated interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Amyl nitrite is a rapid, potent vasodilator, and tadalafil greatly enhances its hypotensive effect. Profound hypotension, collapse and cardiac ischemia can result, including with recreational inhaled nitrites.
O que esta interação significa em palavras simples
Amyl nitrite and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Nitrite-derived nitric oxide raises cGMP and PDE5 inhibition prevents its degradation, causing excessive additive vasodilation.
O que fazer
Do not use together; allow at least 48 hours after the last tadalafil dose before any nitrate. Advise patients to avoid recreational nitrites entirely.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Amyl nitrite e Tadalafil, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Tadalafil
- Isosorbide dinitrate + Tadalafil Contraindicada
- Isosorbide mononitrate + Tadalafil Contraindicada
- Nitroglycerin po + Tadalafil Contraindicada
- Nitroglycerin rectal + Tadalafil Contraindicada
- Nitroglycerin sublingual + Tadalafil Contraindicada
- Nitroglycerin transdermal + Tadalafil Contraindicada
Perguntas frequentes
Can I take Amyl nitrite with Tadalafil?
MediHelp rates the interaction as contraindicated. Amyl nitrite and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Amyl nitrite is a rapid, potent vasodilator, and tadalafil greatly enhances its hypotensive effect. Profound hypotension, collapse and cardiac ischemia can result, including with recreational inhaled nitrites.
How serious is the interaction between Amyl nitrite and Tadalafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; allow at least 48 hours after the last tadalafil dose before any nitrate. Advise patients to avoid recreational nitrites entirely.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Isosorbide dinitrate, Isosorbide mononitrate, Nitroglycerin po. The full list is on the Tadalafil page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
