Interações medicamentosas
Nitroglycerin sublingual + Tadalafil
Gravidade: Contraindicada
Nitroglycerin sublingual and Tadalafil: contraindicated interaction.
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Resumo
Tadalafil markedly potentiates the blood pressure lowering effect of nitrates, including sublingual nitroglycerin. The combination can produce profound, refractory hypotension, syncope and myocardial ischemia, and tadalafil's long half-life means the risk persists for days after a dose.
O que esta interação significa em palavras simples
Nitroglycerin sublingual and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Nitrates raise cGMP via nitric oxide release while tadalafil blocks cGMP breakdown by PDE5, producing excessive additive vasodilation.
O que fazer
Do not use together; nitrates must not be given within 48 hours of the last tadalafil dose. If chest pain occurs within that window, seek emergency care and use non-nitrate measures under medical supervision.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Tadalafil
- Amyl nitrite + Tadalafil Contraindicada
- Isosorbide dinitrate + Tadalafil Contraindicada
- Isosorbide mononitrate + Tadalafil Contraindicada
- Nitroglycerin po + Tadalafil Contraindicada
- Nitroglycerin rectal + Tadalafil Contraindicada
- Nitroglycerin transdermal + Tadalafil Contraindicada
Perguntas frequentes
Can I take Nitroglycerin sublingual with Tadalafil?
MediHelp rates the interaction as contraindicated. Nitroglycerin sublingual and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tadalafil markedly potentiates the blood pressure lowering effect of nitrates, including sublingual nitroglycerin. The combination can produce profound, refractory hypotension, syncope and myocardial ischemia, and tadalafil's long half-life means the risk persists for days after a dose.
How serious is the interaction between Nitroglycerin sublingual and Tadalafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; nitrates must not be given within 48 hours of the last tadalafil dose. If chest pain occurs within that window, seek emergency care and use non-nitrate measures under medical supervision.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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