Interações medicamentosas
Isosorbide dinitrate + Tadalafil
Gravidade: Contraindicada
Isosorbide dinitrate and Tadalafil: contraindicated interaction.
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Resumo
Tadalafil inhibits PDE5 and isosorbide dinitrate releases nitric oxide, together causing a large rise in cGMP in vascular smooth muscle. Profound, sometimes fatal, hypotension and myocardial ischaemia may result.
O que esta interação significa em palavras simples
Isosorbide dinitrate and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isosorbide dinitrate belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Por que acontece
PDE5 inhibition potentiates nitrate-induced cGMP vasodilation
O que fazer
Contraindicated; do not give a nitrate within 48 hours of tadalafil, and use an alternative if both are required.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Tadalafil
- Amyl nitrite + Tadalafil Contraindicada
- Isosorbide mononitrate + Tadalafil Contraindicada
- Nitroglycerin po + Tadalafil Contraindicada
- Nitroglycerin rectal + Tadalafil Contraindicada
- Nitroglycerin sublingual + Tadalafil Contraindicada
- Nitroglycerin transdermal + Tadalafil Contraindicada
Outras interações de Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicada
- Isosorbide dinitrate + Riociguat Contraindicada
- Isosorbide dinitrate + Sildenafil Contraindicada
- Isosorbide dinitrate + Vardenafil Contraindicada
- Ergotamine + Isosorbide dinitrate Grave
- Isosorbide dinitrate + Methylergonovine Grave
Perguntas frequentes
Can I take Isosorbide dinitrate with Tadalafil?
MediHelp rates the interaction as contraindicated. Isosorbide dinitrate and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tadalafil inhibits PDE5 and isosorbide dinitrate releases nitric oxide, together causing a large rise in cGMP in vascular smooth muscle. Profound, sometimes fatal, hypotension and myocardial ischaemia may result.
How serious is the interaction between Isosorbide dinitrate and Tadalafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; do not give a nitrate within 48 hours of tadalafil, and use an alternative if both are required.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide mononitrate, Nitroglycerin po. The full list is on the Tadalafil page.
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