Interações medicamentosas
Ozanimod + Rasagiline
Gravidade: Contraindicada
Ozanimod and Rasagiline: contraindicated interaction.
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Resumo
Ozanimod is metabolised to active metabolites that inhibit MAO-B, so adding an MAO inhibitor may lead to hypertensive crisis or serotonin toxicity, and labeling contraindicates concurrent use. MAO-B inhibitors may also change exposure to ozanimod active metabolites.
O que esta interação significa em palavras simples
Ozanimod and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ozanimod belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Por que acontece
MAO-B inhibition by rasagiline may reduce formation of ozanimod active metabolites and the combined MAO inhibition may cause excess monoamines.
O que fazer
Avoid the combination and consider alternative therapy for multiple sclerosis or Parkinson disease. Allow at least 14 days after stopping ozanimod before starting an MAO inhibitor.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Rasagiline
- Atomoxetine + Rasagiline Contraindicada
- Brimonidine + Rasagiline Contraindicada
- Bupropion-naltrexone + Rasagiline Contraindicada
- Bupropion + Rasagiline Contraindicada
- Clomipramine + Rasagiline Contraindicada
- Desvenlafaxine + Rasagiline Contraindicada
Outras interações de Ozanimod
- Isocarboxazid + Ozanimod Contraindicada
- Linezolid + Ozanimod Contraindicada
- Ozanimod + Phenelzine Contraindicada
- Ozanimod + Procarbazine Contraindicada
- Ozanimod + Safinamide Contraindicada
- Ozanimod + Tranylcypromine Contraindicada
Perguntas frequentes
Can I take Ozanimod with Rasagiline?
MediHelp rates the interaction as contraindicated. Ozanimod and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ozanimod is metabolised to active metabolites that inhibit MAO-B, so adding an MAO inhibitor may lead to hypertensive crisis or serotonin toxicity, and labeling contraindicates concurrent use. MAO-B inhibitors may also change exposure to ozanimod active metabolites.
How serious is the interaction between Ozanimod and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and consider alternative therapy for multiple sclerosis or Parkinson disease. Allow at least 14 days after stopping ozanimod before starting an MAO inhibitor.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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