Interações medicamentosas
Ozanimod + Tranylcypromine
Gravidade: Contraindicada
Ozanimod and Tranylcypromine: contraindicated interaction.
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Resumo
Ozanimod's metabolism involves MAO-B, and its active metabolites may inhibit MAO. Combination with MAO inhibitors could cause hypertensive crisis or altered ozanimod exposure. Labeling contraindicates concurrent use.
O que esta interação significa em palavras simples
Ozanimod and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ozanimod belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Por que acontece
MAO inhibition alters ozanimod metabolite formation, and the metabolites may add MAO inhibition, risking adrenergic excess.
O que fazer
Do not co-administer. Allow at least 14 days between stopping either drug and starting the other, per labeling.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicada
- Amitriptyline + Tranylcypromine Contraindicada
- Amoxapine + Tranylcypromine Contraindicada
- Atomoxetine + Tranylcypromine Contraindicada
- Benzphetamine + Tranylcypromine Contraindicada
- Brimonidine + Tranylcypromine Contraindicada
Outras interações de Ozanimod
- Isocarboxazid + Ozanimod Contraindicada
- Linezolid + Ozanimod Contraindicada
- Ozanimod + Phenelzine Contraindicada
- Ozanimod + Procarbazine Contraindicada
- Ozanimod + Rasagiline Contraindicada
- Ozanimod + Safinamide Contraindicada
Perguntas frequentes
Can I take Ozanimod with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Ozanimod and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ozanimod's metabolism involves MAO-B, and its active metabolites may inhibit MAO. Combination with MAO inhibitors could cause hypertensive crisis or altered ozanimod exposure. Labeling contraindicates concurrent use.
How serious is the interaction between Ozanimod and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Allow at least 14 days between stopping either drug and starting the other, per labeling.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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