Interações medicamentosas
Roxadustat + Simvastatin
Gravidade: Moderada
Roxadustat and Simvastatin: moderate interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Roxadustat raises simvastatin exposure, increasing the chance of statin-related muscle toxicity. Simvastatin is already prone to myopathy at higher exposures.
O que esta interação significa em palavras simples
Roxadustat and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Roxadustat belongs to Miscellaneous; Simvastatin belongs to Cardiovascular.
Por que acontece
Roxadustat inhibits OATP1B1 and BCRP, reducing hepatic uptake and efflux of statins.
O que fazer
Monitor for muscle pain, weakness and CK elevation. Consider reducing the simvastatin dose.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Roxadustat e Simvastatin, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Roxadustat
- Gemfibrozil + Roxadustat Grave
- Probenecid + Roxadustat Grave
- Atorvastatin + Roxadustat Moderada
- Calcium acetate + Roxadustat Moderada
- Calcium + Roxadustat Moderada
- Iron + Roxadustat Moderada
Outras interações de Simvastatin
- Atazanavir + Simvastatin Contraindicada
- Clarithromycin + Simvastatin Contraindicada
- Cobicistat + Simvastatin Contraindicada
- Cyclosporine + Simvastatin Contraindicada
- Cyclosporin + Simvastatin Contraindicada
- Danazol + Simvastatin Contraindicada
Perguntas frequentes
Can I take Roxadustat with Simvastatin?
MediHelp rates the interaction as moderate. Roxadustat and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Roxadustat raises simvastatin exposure, increasing the chance of statin-related muscle toxicity. Simvastatin is already prone to myopathy at higher exposures.
How serious is the interaction between Roxadustat and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness and CK elevation. Consider reducing the simvastatin dose.
What other medicines interact with Roxadustat?
MediHelp also lists interactions of Roxadustat with, for example, Gemfibrozil, Probenecid, Atorvastatin. The full list is on the Roxadustat page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
