Interações medicamentosas
Sodium picosulfate / magnesium oxide / anhydrous citric acid + Tigecycline
Gravidade: Moderada
Sodium picosulfate / magnesium oxide / anhydrous citric acid and Tigecycline: moderate interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Antibiotics may reduce the bowel-cleansing effect of picosulfate preparations by disrupting the colonic bacteria that activate it. The magnesium component could also bind some drugs, although tigecycline is given intravenously so a chelation effect is unlikely to be significant.
O que esta interação significa em palavras simples
Sodium picosulfate / magnesium oxide / anhydrous citric acid and Tigecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Antibiotic suppression of colonic bacteria needed to convert picosulfate to its active metabolite.
O que fazer
Confirm adequate bowel cleansing before the procedure and consider a different preparation if antibiotic therapy cannot be avoided. Do not rely on timing separation, since tigecycline is given intravenously.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Tigecycline
- Tigecycline + Typhoid vaccine live Grave
- Bcg vaccine live + Tigecycline Moderada
- Cholera vaccine + Tigecycline Moderada
- Microbiota + Tigecycline Moderada
- Mipomersen + Tigecycline Moderada
- Balsalazide + Tigecycline Leve
Perguntas frequentes
Can I take Sodium picosulfate / magnesium oxide / anhydrous citric acid with Tigecycline?
MediHelp rates the interaction as moderate. Sodium picosulfate / magnesium oxide / anhydrous citric acid and Tigecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antibiotics may reduce the bowel-cleansing effect of picosulfate preparations by disrupting the colonic bacteria that activate it. The magnesium component could also bind some drugs, although tigecycline is given intravenously so a chelation effect is unlikely to be significant.
How serious is the interaction between Sodium picosulfate / magnesium oxide / anhydrous citric acid and Tigecycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Confirm adequate bowel cleansing before the procedure and consider a different preparation if antibiotic therapy cannot be avoided. Do not rely on timing separation, since tigecycline is given intravenously.
What other medicines interact with Tigecycline?
MediHelp also lists interactions of Tigecycline with, for example, Typhoid vaccine live, Bcg vaccine live, Cholera vaccine. The full list is on the Tigecycline page.
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