Interações medicamentosas
Tigecycline + Typhoid vaccine live
Gravidade: Grave
Tigecycline and Typhoid vaccine live: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Oral live attenuated typhoid vaccine (Ty21a) contains viable bacteria that antibiotics can inactivate, reducing the immune response. Tigecycline is active against Salmonella, so vaccine failure is possible, though the intravenous-only use of tigecycline makes concurrent use uncommon.
O que esta interação significa em palavras simples
Tigecycline and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Antibacterial activity kills or inhibits the live attenuated Salmonella strain, reducing colonisation and immunogenicity.
O que fazer
Delay oral typhoid vaccination until the antibiotic course is complete, or use the inactivated injectable vaccine if immunisation cannot wait.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Tigecycline
Perguntas frequentes
Can I take Tigecycline with Typhoid vaccine live?
MediHelp rates the interaction as major. Tigecycline and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral live attenuated typhoid vaccine (Ty21a) contains viable bacteria that antibiotics can inactivate, reducing the immune response. Tigecycline is active against Salmonella, so vaccine failure is possible, though the intravenous-only use of tigecycline makes concurrent use uncommon.
How serious is the interaction between Tigecycline and Typhoid vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay oral typhoid vaccination until the antibiotic course is complete, or use the inactivated injectable vaccine if immunisation cannot wait.
What other medicines interact with Tigecycline?
MediHelp also lists interactions of Tigecycline with, for example, Bcg vaccine live, Cholera vaccine, Microbiota. The full list is on the Tigecycline page.
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